Neutralizing activities against seasonal influenza viruses in human intravenous immunoglobulin
Identifieur interne : 000288 ( Main/Exploration ); précédent : 000287; suivant : 000289Neutralizing activities against seasonal influenza viruses in human intravenous immunoglobulin
Auteurs : Hiroyuki Onodera ; Takeru Urayama [Japon] ; Kazue Hirota ; Kazuhiro Maeda ; Ritsuko Kubota-Koketsu ; Kazuo Takahashi ; Katsuro Hagiwara [Japon] ; Yoshinobu Okuno ; Kazuyoshi Ikuta ; Mikihiro Yunoki [Japon]Source :
- Biologics : Targets & Therapy [ 1177-5475 ] ; 2017.
Abstract
Influenza viruses A/H1N1, A/H3N2, and B are known seasonal viruses that undergo annual mutation. Intravenous immunoglobulin (IVIG) contains anti-seasonal influenza virus globulins. Although the virus-neutralizing (VN) titer is an indicator of protective antibodies, changes in this titer over extended time periods have yet to be examined. In this study, variations in hemagglutination inhibition (HI) and VN titers against seasonal influenza viruses in IVIG lots over extended time periods were examined. In addition, the importance of monitoring the reactivity of IVIG against seasonal influenza viruses with varying antigenicity was evaluated. A/H1N1, A/H3N2, and B influenza virus strains and IVIG lots manufactured from 1999 to 2014 were examined. The HI titer was measured by standard methods. The VN titer was measured using a micro-focus method. IVIG exhibited significant HI and VN titers against all investigated strains. Our results suggest that the donor population maintains both specific and cross-reactive antibodies against seasonal influenza viruses, except in cases of pandemic viruses, despite major antigen changes. The titers against seasonal influenza vaccine strains, including past strains, were stable over short time periods but increased slowly over time.
Url:
DOI: 10.2147/BTT.S123831
PubMed: 28331286
PubMed Central: 5354529
Affiliations:
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Department</nlm:aff></affiliation></author><author><name sortKey="Urayama, Takeru" sort="Urayama, Takeru" uniqKey="Urayama T" first="Takeru" last="Urayama">Takeru Urayama</name><affiliation wicri:level="3"><nlm:aff id="af2-btt-11-023">Research and Development Division, Japan Blood Products Organization, Tokyo</nlm:aff><country>Japon</country><placeName><settlement type="city">Tokyo</settlement><region type="région">Région de Kantō</region></placeName><wicri:orgArea>Research and Development Division, Japan Blood Products Organization</wicri:orgArea></affiliation></author><author><name sortKey="Hirota, Kazue" sort="Hirota, Kazue" uniqKey="Hirota K" first="Kazue" last="Hirota">Kazue Hirota</name><affiliation><nlm:aff id="af3-btt-11-023">Research and Development Division, The Research Foundation for Microbial Diseases of Osaka University, Kagawa</nlm:aff><wicri:noCountry code="subfield">Kagawa</wicri:noCountry></affiliation></author><author><name sortKey="Maeda, Kazuhiro" sort="Maeda, Kazuhiro" uniqKey="Maeda K" first="Kazuhiro" last="Maeda">Kazuhiro Maeda</name><affiliation><nlm:aff id="af3-btt-11-023">Research and Development Division, The Research Foundation for Microbial Diseases of Osaka University, Kagawa</nlm:aff><wicri:noCountry code="subfield">Kagawa</wicri:noCountry></affiliation></author><author><name sortKey="Kubota Koketsu, Ritsuko" sort="Kubota Koketsu, Ritsuko" uniqKey="Kubota Koketsu R" first="Ritsuko" last="Kubota-Koketsu">Ritsuko Kubota-Koketsu</name><affiliation><nlm:aff id="af3-btt-11-023">Research and Development Division, The Research Foundation for Microbial Diseases of Osaka University, Kagawa</nlm:aff><wicri:noCountry code="subfield">Kagawa</wicri:noCountry></affiliation><affiliation><nlm:aff id="af4-btt-11-023">Former Department of Virology, Research Institute for Microbial Diseases, Osaka University</nlm:aff><wicri:noCountry code="subfield">Osaka University</wicri:noCountry></affiliation></author><author><name sortKey="Takahashi, Kazuo" sort="Takahashi, Kazuo" uniqKey="Takahashi K" first="Kazuo" last="Takahashi">Kazuo Takahashi</name><affiliation><nlm:aff id="af5-btt-11-023">Virology Division, Department of Infectious Diseases, Osaka Prefectural Institute of Public Health, Osaka</nlm:aff><wicri:noCountry code="subfield">Osaka</wicri:noCountry></affiliation></author><author><name sortKey="Hagiwara, Katsuro" sort="Hagiwara, Katsuro" uniqKey="Hagiwara K" first="Katsuro" last="Hagiwara">Katsuro Hagiwara</name><affiliation wicri:level="1"><nlm:aff id="af6-btt-11-023">Pathogenic Risk Evaluation, Graduate School of Veterinary Medicine, Rakuno Gakuen University, Hokkaido, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Pathogenic Risk Evaluation, Graduate School of Veterinary Medicine, Rakuno Gakuen University, Hokkaido</wicri:regionArea><wicri:noRegion>Hokkaido</wicri:noRegion></affiliation></author><author><name sortKey="Okuno, Yoshinobu" sort="Okuno, Yoshinobu" uniqKey="Okuno Y" first="Yoshinobu" last="Okuno">Yoshinobu Okuno</name><affiliation><nlm:aff id="af3-btt-11-023">Research and Development Division, The Research Foundation for Microbial Diseases of Osaka University, Kagawa</nlm:aff><wicri:noCountry code="subfield">Kagawa</wicri:noCountry></affiliation></author><author><name sortKey="Ikuta, Kazuyoshi" sort="Ikuta, Kazuyoshi" uniqKey="Ikuta K" first="Kazuyoshi" last="Ikuta">Kazuyoshi Ikuta</name><affiliation><nlm:aff id="af3-btt-11-023">Research and Development Division, The Research Foundation for Microbial Diseases of Osaka University, Kagawa</nlm:aff><wicri:noCountry code="subfield">Kagawa</wicri:noCountry></affiliation><affiliation><nlm:aff id="af4-btt-11-023">Former Department of Virology, Research Institute for Microbial Diseases, Osaka University</nlm:aff><wicri:noCountry code="subfield">Osaka University</wicri:noCountry></affiliation></author><author><name sortKey="Yunoki, Mikihiro" sort="Yunoki, Mikihiro" uniqKey="Yunoki M" first="Mikihiro" last="Yunoki">Mikihiro Yunoki</name><affiliation wicri:level="3"><nlm:aff id="af2-btt-11-023">Research and Development Division, Japan Blood Products Organization, Tokyo</nlm:aff><country>Japon</country><placeName><settlement type="city">Tokyo</settlement><region type="région">Région de Kantō</region></placeName><wicri:orgArea>Research and Development Division, Japan Blood Products Organization</wicri:orgArea></affiliation><affiliation><nlm:aff id="af4-btt-11-023">Former Department of Virology, Research Institute for Microbial Diseases, Osaka University</nlm:aff><wicri:noCountry code="subfield">Osaka University</wicri:noCountry></affiliation><affiliation wicri:level="1"><nlm:aff id="af6-btt-11-023">Pathogenic Risk Evaluation, Graduate School of Veterinary Medicine, Rakuno Gakuen University, Hokkaido, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Pathogenic Risk Evaluation, Graduate School of Veterinary Medicine, Rakuno Gakuen University, Hokkaido</wicri:regionArea><wicri:noRegion>Hokkaido</wicri:noRegion></affiliation></author></analytic><series><title level="j">Biologics : Targets & Therapy</title><idno type="ISSN">1177-5475</idno><idno type="eISSN">1177-5491</idno><imprint><date when="2017">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Influenza viruses A/H1N1, A/H3N2, and B are known seasonal viruses that undergo annual mutation. Intravenous immunoglobulin (IVIG) contains anti-seasonal influenza virus globulins. Although the virus-neutralizing (VN) titer is an indicator of protective antibodies, changes in this titer over extended time periods have yet to be examined. In this study, variations in hemagglutination inhibition (HI) and VN titers against seasonal influenza viruses in IVIG lots over extended time periods were examined. In addition, the importance of monitoring the reactivity of IVIG against seasonal influenza viruses with varying antigenicity was evaluated. A/H1N1, A/H3N2, and B influenza virus strains and IVIG lots manufactured from 1999 to 2014 were examined. The HI titer was measured by standard methods. The VN titer was measured using a micro-focus method. IVIG exhibited significant HI and VN titers against all investigated strains. Our results suggest that the donor population maintains both specific and cross-reactive antibodies against seasonal influenza viruses, except in cases of pandemic viruses, despite major antigen changes. The titers against seasonal influenza vaccine strains, including past strains, were stable over short time periods but increased slowly over time.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Pichyangkul, S" uniqKey="Pichyangkul S">S Pichyangkul</name></author><author><name sortKey="Jongkaewwattana, A" uniqKey="Jongkaewwattana A">A Jongkaewwattana</name></author><author><name sortKey="Thitithanyanont, A" uniqKey="Thitithanyanont A">A Thitithanyanont</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yunoki, M" uniqKey="Yunoki M">M Yunoki</name></author><author><name sortKey="Kubota Koketsu, R" uniqKey="Kubota Koketsu R">R Kubota-Koketsu</name></author><author><name sortKey="Urayama, T" uniqKey="Urayama T">T Urayama</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hong, Dk" uniqKey="Hong D">DK Hong</name></author><author><name sortKey="Tremoulet, Ah" uniqKey="Tremoulet A">AH Tremoulet</name></author><author><name sortKey="Burns, Jc" uniqKey="Burns J">JC Burns</name></author><author><name sortKey="Lewis, Db" uniqKey="Lewis D">DB Lewis</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kubota Koketsu, R" uniqKey="Kubota Koketsu R">R Kubota-Koketsu</name></author><author><name sortKey="Yunoki, M" uniqKey="Yunoki M">M Yunoki</name></author><author><name sortKey="Okuno, Y" uniqKey="Okuno Y">Y Okuno</name></author><author><name sortKey="Ikuta, K" uniqKey="Ikuta K">K Ikuta</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Okuno, Y" uniqKey="Okuno Y">Y Okuno</name></author><author><name sortKey="Tanaka, K" uniqKey="Tanaka K">K Tanaka</name></author><author><name sortKey="Baba, K" uniqKey="Baba K">K Baba</name></author><author><name sortKey="Maeda, A" uniqKey="Maeda A">A Maeda</name></author><author><name sortKey="Kunita, N" uniqKey="Kunita N">N Kunita</name></author><author><name sortKey="Ueda, S" uniqKey="Ueda S">S Ueda</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Gokturk, B" uniqKey="Gokturk B">B Gokturk</name></author><author><name sortKey="Pekcan, S" uniqKey="Pekcan S">S Pekcan</name></author><author><name sortKey="Guner, Sn" uniqKey="Guner S">SN Guner</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Davey, Rt" uniqKey="Davey R">RT Davey</name></author><author><name sortKey="Markowitz, N" uniqKey="Markowitz N">N Markowitz</name></author><author><name sortKey="Beigel, J" uniqKey="Beigel J">J Beigel</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Donovan, S" uniqKey="Donovan S">S Donovan</name></author><author><name sortKey="Bearman, Gm" uniqKey="Bearman G">GM Bearman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hung, If" uniqKey="Hung I">IF Hung</name></author><author><name sortKey="To, Kk" uniqKey="To K">KK To</name></author><author><name sortKey="Lee, Ck" uniqKey="Lee C">CK Lee</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hagiwara, K" uniqKey="Hagiwara K">K Hagiwara</name></author><author><name sortKey="Kawami, S" uniqKey="Kawami S">S Kawami</name></author><author><name sortKey="Kato Mori, Y" uniqKey="Kato Mori Y">Y Kato-Mori</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hohenadl, C" uniqKey="Hohenadl C">C Hohenadl</name></author><author><name sortKey="Wodal, W" uniqKey="Wodal W">W Wodal</name></author><author><name sortKey="Kerschbaum, A" uniqKey="Kerschbaum A">A Kerschbaum</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Japon</li></country><region><li>Région de Kantō</li></region><settlement><li>Tokyo</li></settlement></list><tree><noCountry><name sortKey="Hirota, Kazue" sort="Hirota, Kazue" uniqKey="Hirota K" first="Kazue" last="Hirota">Kazue Hirota</name><name sortKey="Ikuta, Kazuyoshi" sort="Ikuta, Kazuyoshi" uniqKey="Ikuta K" first="Kazuyoshi" last="Ikuta">Kazuyoshi Ikuta</name><name sortKey="Kubota Koketsu, Ritsuko" sort="Kubota Koketsu, Ritsuko" uniqKey="Kubota Koketsu R" first="Ritsuko" last="Kubota-Koketsu">Ritsuko Kubota-Koketsu</name><name sortKey="Maeda, Kazuhiro" sort="Maeda, Kazuhiro" uniqKey="Maeda K" first="Kazuhiro" last="Maeda">Kazuhiro Maeda</name><name sortKey="Okuno, Yoshinobu" sort="Okuno, Yoshinobu" uniqKey="Okuno Y" first="Yoshinobu" last="Okuno">Yoshinobu Okuno</name><name sortKey="Onodera, Hiroyuki" sort="Onodera, Hiroyuki" uniqKey="Onodera H" first="Hiroyuki" last="Onodera">Hiroyuki Onodera</name><name sortKey="Takahashi, Kazuo" sort="Takahashi, Kazuo" uniqKey="Takahashi K" first="Kazuo" last="Takahashi">Kazuo Takahashi</name></noCountry><country name="Japon"><region name="Région de Kantō"><name sortKey="Urayama, Takeru" sort="Urayama, Takeru" uniqKey="Urayama T" first="Takeru" last="Urayama">Takeru Urayama</name></region><name sortKey="Hagiwara, Katsuro" sort="Hagiwara, Katsuro" uniqKey="Hagiwara K" first="Katsuro" last="Hagiwara">Katsuro Hagiwara</name><name sortKey="Yunoki, Mikihiro" sort="Yunoki, Mikihiro" uniqKey="Yunoki M" first="Mikihiro" last="Yunoki">Mikihiro Yunoki</name><name sortKey="Yunoki, Mikihiro" sort="Yunoki, Mikihiro" uniqKey="Yunoki M" first="Mikihiro" last="Yunoki">Mikihiro Yunoki</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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